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Pendrin, also known as sodium-independent chloride/iodide transporter, is an antiporter anion exchanger protein that in humans is encoded by the ''SLC26A4'' gene (solute carrier family 26, member 4).〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5172 )〕 Pendrin is similar to the Band 3 transport protein found in red blood cells. Pendrin is the protein which is mutated in Pendred syndrome, which is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter and a partial organification problem detectable by a positive perchlorate test. Pednrin is an antiporter anion exchanger similar to the Band 3 transport protein found in red blood cells. Pendrin is responsible for mediating the electroneutral exchange of chloride (Cl−) for bicarbonate (HCO3−) across a plasma membrane in the chloride cells of freshwater fish. By phylogenetic analysis, pendrin has been found to be a close relative of prestin present on the hair cells or organ of corti in the inner ear. Prestin is primarily an electromechanical transducer but pendrin is an ion transporter. Pendrin is also thought to be responsible for mediating the electroneutral exchange of chloride (Cl−) for bicarbonate (HCO3−) across a plasma membrane in the chloride cells of freshwater fish. == Function == Pendrin is an ion exchanger found in many types of cells in the body. For example it is found in the cortical collecting duct lining cells in the kidney. Pendrin is found at the apical (luminal) membrane of follicular cells in the thyroid gland. It transports iodide from the cytoplasm to the follicle lumen. Its activity is necessary for production of thyroid hormone. Pendrin is also found in the cells of the inner ear, where its function is not well understood. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pendrin」の詳細全文を読む スポンサード リンク
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