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''Penicillium'' species are usually regarded as unimportant in terms of causing human disease. ''Penicillium marneffei'', discovered in 1956, is different. This is the only known thermally dimorphic species of ''Penicillium'', and it can cause a lethal systemic infection (penicilliosis) with fever and anaemia similar to disseminated cryptococcosis. ==Epidemiology== There is a high incidence of penicilliosis in AIDS patients in SE Asia; 10% of patients in Hong Kong get penicillosis as an AIDS-related illness. Cases of ''P. marneffei'' human infections (penicillosis) have also been reported in HIV-positive patients in Australia, Europe, Japan, the UK and the U.S.. All the patients, except one, had visited Southeast Asia previously. Discovered in bamboo rats (''Rhizomys'') in Vietnam, it is associated with these rats and the tropical Southeast Asia area. ''Penicillium marneffei'' is endemic in Burma (Myanmar), Cambodia, Southern China, Indonesia, Laos, Malaysia, Thailand and Vietnam. Although both the immunocompetent and the immunocompromised can be infected, it is extremely rare to find systemic infections in HIV-negative patients. The incidence of ''P. marneffei'' is increasing as HIV spreads throughout Asia. An increase in global travel and migration means it will be of increased importance as an infection in AIDS sufferers. ''Penicillium marneffei'' has been found in bamboo rat faeces, liver, lungs and spleen. It has been suggested that these animals are a reservoir for the fungus. It is not clear whether the rats are affected by ''P. marneffei'' or are merely asymptomatic carriers of the disease. One study of 550 AIDS patients showed that the incidence was higher during the rainy season, which is when the rats breed but also when conditions are more favorable for production of fungal spores (conidia) that can become airborne and be inhaled by susceptible individuals. Another study could not establish contact with bamboo rats as a risk factor, but exposure to the soil was the critical risk factor. However, soil samples failed to yield much of the fungus. It is not known whether people get the disease by eating infected rats, or by inhaling fungi from their faeces. There is an example of an HIV-positive physician who was infected while attending a course on tropical microbiology. He did not handle the organism, though students in the same laboratory did. It is presumed he contracted the infection by inhaling aerosol containing ''P. marneffei'' conidia. This shows that airborne infections are possible. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Penicillium marneffei」の詳細全文を読む スポンサード リンク
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