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・ Pepa Pavlova
・ Pepa, Democratic Republic of the Congo
・ Pepacton Reservoir
・ Pepala vari palem
・ PEPAP
・ Pepato
・ PepB aminopeptidase
・ Pepbi Bala
・ Pepbi Paeen (Hakimabad)
・ Pepcid Complete
・ PEPCO
・ Pepco
・ Pepco Holdings
・ PEPCON disaster
・ PEPD
Pepducin
・ Pepe
・ Pepe & Fifi
・ Pepe (film)
・ Pepe (footballer, born 1935)
・ Pepe (footballer, born 1983)
・ Pepe (Haiti)
・ Pepe (song)
・ Pepe Abad
・ Pepe Aguilar
・ Pepe Arias
・ Pepe Barreto
・ Pepe Brand
・ Pepe Carvalho
・ Pepe Cayuela


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Pepducin : ウィキペディア英語版
Pepducin
Pepducins are novel cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.
Pepducins utilize lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways. A Pepducin molecule comprises a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety. This structure allows Pepducin lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein interface via a unique intracellular allosteric mechanism. Pepducins for over 15 different GPCRs have been successfully produced, several of which have shown activity in preclinical ''in vivo'' models.
An anti-PAR4 pepducin extended bleeding time in mice and protected against systemic platelet activation and thrombosis.〔
A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells.〔(【引用サイトリンク】title=Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. )
A PAR1 pepducin, PZ-128, has successfully completed phase I clinical trials, and progress continues to be made.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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