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Perdesonide
Perdesonide is a glucocorticoid steroid. It is closely related to budesonide and differs by having a difluorinated steroid skeleton. The introduction of the 2 fluorines to the steroid skeleton was shown to increase systemic activity to a greater degree than local activity.〔“Drug Development of Inhaled Steroids: A Pharmacologist's View Based on Experiences from the Budesonide Project,” Lung Biology in Health and Disease, vol 163, chapter 1〕 Perdesonide resembles clocortolone in that both have two halide atoms; perdesonide has two fluorine atoms and clocortolone has one chlorine atom and one fluorine atom.〔“Foye's Principles of Medicinal Chemistry”〕 Perdesonide is racemic at the carbon of the acetal. The R-isomer of the acetal as in (R)-Perdesonide is more active. ==See also==
* Budesonide * (R)-Perdesonide * Clocortolone
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Perdesonide」の詳細全文を読む
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