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Electroencephalography (EEG) is the science of recording the spontaneous rhythmic electrical activity of a living brain through electrodes on the scalp. Brain rhythms have origins similar to the electrical activity of the heart. The rhythmic activity varies in frequency and amplitude with age, attention, sleep, and chemical concentrations of oxygen, carbon dioxide, glucose, ammonia, and hormones. Chemicals that affect brain functions change brain rhythms in systematic and identifiable ways. As new psychoactive drugs were discovered that changed behavior, the basis for the science of psychopharmacology, the accompanying changes in the rhythms were found to be drug class specific. The measurement of the changes in rhythms became the basis for the science of pharmaco-EEG. Definitions of the changes in EEG rhythms were developed that identified and classified psychoactive drugs, monitored the depth of anesthesia, and evaluated the efficacy of the seizures induced in convulsive therapy (electroshock). == History == The first recordings of electrical activity from the brain were reported from exposed animal brain tissues in the 1870s. In 1929 Hans Berger, a German psychiatrist, reported continuous electrical rhythms from the intact human head using electrodes on the scalp. The continuous electrical activity varied in frequencies and amplitude with drowsiness and sleep, and with mental problem solving. Episodic runs and bursts of high voltage slow frequencies were recorded in patients with epilepsy. In his third report in 1931 Berger recorded changes in the rhythms with cocaine, morphine, scopolamine, and chloroform. Each chemical elicited different frequency and amplitude patterns and different behaviors. The first clinical applications were in identifying the sudden bursts of high voltage slow frequencies during seizures, both spontaneous and induced by the chemical pentylenetetrazol (Metrazol), by electricity in electroshock, and in the coma induced by insulin. When reserpine was studied in 1953, chlorpromazine in 1954, and imipramine in 1957, individual rhythmic patterns were described. The EEG patterns of new psychoactive drugs predicted their clinical activity. By the 1960s, EEG analysis of psychoactive drugs was a feature of the NIMH Early Clinical Drug Evaluation (ECDEU) program that evaluated and identified new psychiatric treatments. Proposed psychoactive drugs developed in chemical laboratories were first tested in animals and then tested in man. The changes in the EEG became the basis for a classification of new drugs. Assessment methods in human volunteers were developed that recorded the changes in the resting subject at different dosages, both on acute single administrations and repeated daily dosing. The observed changes were compared to those for known drugs and predicted their behavioral effects. When no systematic changes were recorded, the agents were considered not to have a clinical use. Dosing schedules were optimized. In patients who failed to respond to prescribed treatments, those who were considered "pharmacotherapy resistant," EEG studies showed that the chemicals did not elicit identifiable brain changes. In pre-clinical animal trials EEG recordings were associated the changes with vigilance and motor measures, concluding that the EEG patterns were "dissociated," that is, bearing little relationship to the changes in behavior. In human trials, however, when the EEG measures could be related to vigilance, mood, memory, and psychological tests, a theory of "association of EEG and behavior" developed and sustained pharmaco-EEG studies of new drugs. The technology was applied in anesthesia, identifying the efficacy of individual seizures in convulsive therapy, in studies of sleep patterns, and the relation of evoked potentials to speech and psychological tests. Social changes in attitudes to the ethics of testing drugs and treatments in patients, prisoners, children, and volunteers inhibited the continued development of the science and its abandonment. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pharmaco-electroencephalography」の詳細全文を読む スポンサード リンク
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