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Phaseolamin
Phaseolamin is a generic name for a proteinaceous inhibitor of the enzyme alpha-amylase that is made from white beans. A number of amylase inhibitors from white beans have been marketed over the years as weight control remedies.
== Background ==
As reported in the Journal of the American Medical Association (JAMA), early phaseolamin products did not have sufficient potency or stability to effect any in vivo changes. In addition, impurities contained therein caused complaints of GI distress including flatulence. In the late 1990s, the first standardized starch blocker, "Phase 2 Carb Controller" (also known as StarchLite), was developed . Phase 2 is a fractionated white kidney bean extract that has been clinically shown in 13 studies to delay the digestion and absorption of starch calories. Phase 2 neutralizes some of the digestive enzyme alpha amylase, temporarily delaying the digestion and absorption of carbohydrates, allowing a portion of them to pass through the system before they can be converted into glucose, and then fat. Phase 2 is generally recognized as safe (GRAS) and usually does not cause side effects. Phase 2 is available as an ingredient that can be formulated in a variety of nutritional supplements, foods and beverages. It is also sold as "StarchLite" in Europe.
In 2006, the Food and Drug Administration, based on clinical data and information submitted to the agency, announced that it does not object to weight control and starch reduction claims for Phase 2, and finished dietary supplement products containing the ingredient. With this announcement, Phase 2 became the first nutritional ingredient with two permitted structure/function claims: 1) May assist in weight control when used in conjunction with a sensible diet and exercise, and 2) May reduce the enzymatic digestion of dietary starches.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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