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・ Phenacovolva parvita
・ Phenacovolva patriciae
・ Phenacovolva philippinarum
・ Phenacovolva poppei
・ Phenacovolva pseudogracilis
・ Phenacovolva recurva
・ Phenacovolva rehderi
・ Phenacovolva rosea
・ Phenacovolva schmidi
・ Phenacovolva subreflexa
・ Phenacovolva zuidafrikaana
・ Phenacyl
・ Phenacyl bromide
・ Phenacyl chloride
・ Phenadoxone
Phenaglycodol
・ Phenagoniates macrolepis
・ Phenakistoscope
・ Phenakite
・ Phenakospermum
・ Phenalene
・ Phenamidine
・ Phenampromide
・ Phenanthrene
・ Phenanthrenoid
・ Phenanthridine
・ Phenanthriplatin
・ Phenanthroline
・ Phenaridine
・ Phenatoma


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Phenaglycodol : ウィキペディア英語版
Phenaglycodol

Phenaglycodol (INN, BAN; brand names Acalmid, Acalo, Alterton, Atadiol, Felixyn, Neotran, Pausital, Remin, Sedapsin, Sinforil, Stesil, Ultran) is a drug described as a tranquilizer or sedative which has anxiolytic and anticonvulsant properties. It is related structurally and pharmacologically to meprobamate, though it is not a carbamate.
==Synthesis==

''p''-Chloroacetophenone and NaCN are reacted together to give the corresponding cyanohydrin (cf Strecker synthesis). The cyano group is then partially hydrolyzed in acid to the corresponding amide, thus ''p''-chloroatrolactamide (4) is formed. The amide group is then further hydrolyzed with a 2nd equivalent of water in concentrated lye to ''p''-chloroatrolactic acid (5); this is then esterified to Ethyl ''p''-chloroatrolactate (6). Finally, nucleophilic addition a couple of equivalents of MeMgI are added to the ester give Phenaglycodol (7) crystals.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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