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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phenibut ： ウィキペディア英語版 Phenibut Phenibut (or, alternatively, fenibut, phenybut) (brand name Noofen, Citrocard), contracted from ''β-phenyl-γ-aminobutyric acid'' (β-phenyl-GABA), is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA). The addition of a phenyl ring allows phenibut to cross the blood–brain barrier.〔 Phenibut was developed in the Soviet Union in the 1960s, and has since been used there as a pharmaceutical drug to treat a wide range of ailments, including posttraumatic stress disorder, anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders, among other conditions.〔〔 In the rest of the world, phenibut is not approved for clinical use, and is instead sold as a nutritional supplement.〔 It has been reported by some researchers to possess nootropic actions for its ability to improve neurological functions,〔 but others have not observed these effects.〔 It is generally accepted that phenibut has anxiolytic effects in both animal models and in humans.〔 Phenibut is a close structural analogue of GABA, as well as of baclofen (β-(4-chlorophenyl)-GABA), pregabalin (β-isobutyl-GABA), and GABOB (β-hydroxy-GABA). Originally thought to act as a selective GABAB receptor agonist, phenibut has since been found to act preferentially as a blocker of α2δ subunit-containing voltage-gated calcium channels, similarly to gabapentin and pregabalin. As such, phenibut is a gabapentinoid. ==History== Phenibut was synthesized at the A. I. Herzen Leningrad Pedagogical Institute (USSR) by Professor Vsevolod Perekalin's team and tested at the Institute of Experimental Medicine, USSR Academy of Medical Sciences. Phenibut is mandated standard equipment in a Russian cosmonaut's medical kit. The use of "conventional" tranquilizers for stress and anxiety makes patients drowsy, which was deemed unacceptable for cosmonauts; phenibut, however, lowers stress levels without adversely affecting performance. In 1975 phenibut was included in the cosmonauts' kit for those who participated in the Apollo-Soyuz joint mission.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phenibut」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.