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Phlobaphene
Phlobaphenes (or phlobaphens, CAS No.:71663-19-9) are reddish, alcohol-soluble and water-insoluble phenolic substances. They can be extracted from plants, or be the result from treatment of tannin extracts with mineral acids (tanner's red). The name ''phlobaphen'' come from the Greek roots φλoιὀς (''phloios'') meaning bark and βαφή (''baphe'') meaning dye.〔Römpp CD 2006, Georg Thieme Verlag 2006〕 No biological activities have currently been reported for phlobaphenes.〔(Phlobaphene on Dr. Duke's Phytochemical and Ethnobotanical Databases )〕 Phlobaphenes from hawthorn fruits (''Fructus Crataegi'') may have a specific action on the coronary circulation. They are converted into humins in soils.〔(A Manual of pharmacology and its applications to therapeutics and toxicology by Torald Sollmann, M. D. )〕 == Naturally formed phlobaphenes == Natural phlobaphenes are the common bark, pericarp, cob glume and seed coat (''testa'') pigments. They have not been found in flowers, unless the brown and black pigments in the involucrum of certain compositae are found to be of the phlobaphen type. In bark, phlobaphenes accumulate in the phellem layer of cork cambium, part of the suberin mixture.〔 Par James A. Duke〕
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