翻訳と辞書 Words near each other ・ Phosphorus-32 ・ Phosphoryl bromide ・ Phosphoryl chloride ・ Phosphoryl chloride (data page) ・ Phosphoryl fluoride ・ Phosphoryl group ・ Phosphoglycolate phosphatase ・ Phosphogypsum ・ Phosphohydroxypyruvic acid ・ Phosphoinositide 3-kinase ・ Phosphoinositide 3-kinase inhibitor ・ Phosphoinositide 5-phosphatase ・ Phosphoinositide phospholipase C ・ Phosphoinositide-dependent kinase-1 ・ Phosphoketolase ・ Phospholamban ・ Phosphole ・ Phospholipase ・ Phospholipase A ・ Phospholipase A1 ・ Phospholipase A2 ・ Phospholipase B ・ Phospholipase C ・ Phospholipase D ・ Phospholipase D1 ・ Phospholipid ・ Phospholipid acyltransferase ・ Phospholipid scramblase ・ Phospholipid transfer protein ・ Phospholipid-derived fatty acids Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phospholamban ： ウィキペディア英語版 Phospholamban Phospholamban, also known as PLN or PLB, is a protein that in humans is encoded by the ''PLN'' gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. == Function == This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase (PKA) in cardiac muscle. The protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca++-ATPase (SERCA) in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca++ pump leads to shorter intervals between contractions, thereby contributing to the lusitropic response elicited in heart by beta-agonists. The protein is a key regulator of . Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5350 )〕 When phospholamban is phosphorylated by its ability to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation), may enhance the rate of cardiac myocyte relaxation. In addition, since SERCA is more active, the next action potential will cause an increased release of calcium, resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA. The overall effect of phospholamban is to decrease and the rate of , thereby decreasing stroke volume and heart rate, respectively. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phospholamban」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.