翻訳と辞書 Words near each other ・ Piran Dam ・ Piran Ghaib railway station ・ Piran Gushnasp ・ Piran Holloway ・ Piran Kaliyar Sharif ・ Piran Minorite Monastery ・ Piran Rural District ・ Piran, Azerbaijan ・ Piran, Chaharmahal and Bakhtiari ・ Piran, Hirmand ・ Piran, Iraq ・ Piran, Kermanshah ・ Pirana, Rajasthan ・ Piranch ・ Pirancheri ・ Pirandamine ・ Piranema River ・ Piranesi ・ Piranesi (Software) ・ Piranesi Vase ・ Piranga ・ Piranga, Minas Gerais ・ Pirangi ・ Pirangi River ・ Pirangoclytus ・ Pirangoclytus amaryllis ・ Pirangoclytus chaparensis ・ Pirangoclytus flavius ・ Pirangoclytus fraternus ・ Pirangoclytus granulipennis Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Pirandamine ： ウィキペディア英語版 Pirandamine Pirandamine (AY-23,713) is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor (SSRI). It was investigated in the 1970s as a potential antidepressant but clinical development was not commenced and it was never marketed.〔 Pirandamine is structurally related to tandamine, which, in contrast, is a selective norepinephrine reuptake inhibitor.〔〔 ==Synthesis== Condesation of 1-indanone (1) with ethyl bromoacetate and zinc addords Reformatsky reaction product 2; then reduction with LiAlH4 gives diol 3. Dehydration with H2SO4 gives the indene ethanol 4. Acid catalyzed condensation of 4 with ethyl acetoacetate then gives the fused tetrahydropyran derivative 5 (no doubt by a scheme quite analogous to prodolic acid). The ester is then saponified to the corresponding acid, which is then converted to the dimethylamide (6). Reduction with LiAlH4 completes the synthesis of the antidepressant agent pirandamine (7). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pirandamine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.