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Plastoquinone
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Plastoquinone : ウィキペディア英語版
Plastoquinone

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Plastoquinone (PQ) is a quinone molecule involved in the electron transport chain in the light-dependent reactions of photosynthesis. Plastoquinone is reduced (accepts two protons (H+) from the stromal matrix of the chloroplast, coupled to two electrons (e) from photosystem II), forming plastoquinol. It transports the protons to the lumen of thylakoid discs, while the electrons continue through the electron transport chain into the cytochrome ''b''6''f'' protein complex.
The prefix ''plasto-'' means either plastid or chloroplast, alluding to its location within the cell.〔http://dictionary.reference.com/browse/Plastoquinone Definition of plastoquinone〕
Structurally it is a 2,3-dimethyl-1,4-benzoquinone molecule with a side chain of nine isoprenyl units.
==Derivatives==
Some derivatives designed to penetrate cell membranes (SkQ1 (plastoquinonyl-decyl-triphenylphosphonium), SkQR1 (the rhodamine-containing analog of SkQ1), SkQ3) have anti-oxidant and protonophore activity.
SkQ1 is proposed as an anti-aging treatment.〔(【引用サイトリンク】title=An attempt to prevent senescence: A mitochondrial approach. )〕〔http://protein.bio.msu.ru/biokhimiya/contents/v73/pdf/bcm_1329.pdf Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt Execution of the Aging Program. 5. SkQ1 Prolongs Lifespan and Prevents Development of Traits of Senescence. Anisimov etal. 2008〕
SkQ1 is starting clinical trials for glaucoma in Russia.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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