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Pleconaril : ウィキペディア英語版
Pleconaril

Pleconaril (Picovir〔http://pharma.financialexpress.com/20011227/research1.htm〕) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. Pleconaril, administered either orally or intranasally, is active against viruses in the ''Picornaviridae'' family, including ''Enterovirus'' and ''Rhinovirus''. It has shown useful activity against the dangerous strain enterovirus D68.〔Liu Y et al., Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. ''Science'', 2015; 347 (6217): 71 DOI: 10.1126/science.1261962〕
==History==
Pleconaril was originally developed by Sanofi-Aventis, and licensed to ViroPharma in 1997. ViroPharma developed it further, and submitted a New Drug Application to the United States Food and Drug Administration (FDA) in 2001. The application was rejected, citing safety concerns; and ViroPharma re-licensed it to Schering-Plough in 2003. The Phase II clinical trial was completed in 2007.〔 A pleconaril intranasal spray had reached phase II clinical trial for the treatment of the common cold symptoms and asthma complications. However, the results have yet to be reported.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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