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PolyHeme
PolyHeme is a temporary oxygen-carrying blood substitute made from human hemoglobin that is in development for emergency treatment of trauma situations where large volumes of blood are lost, with emphasis on situations where fresh blood for transfusion is not readily available. It originally began as a military project following the Vietnam war and is being developed by Northfield Laboratories, Inc.
== Production ==
PolyHeme is a solution of human hemoglobin extracted from red blood cells that has been modified using a multi-step polymerization process. The purified hemoglobin is associated into tetramers and is incorporated into an electrolyte solution. The polymerization of the hemoglobin represents the critical advance in the development of artificial blood. Previous attempts using non-polymerized hemoglobin caused vasoconstriction. Also, filtration of free globin chains by the kidney causes renal failure. The company uses expired human blood from which the hemoglobin is extracted and purified. The hemoglobin molecule is then pyridoxylated to raise its P50. Subsequently, this hemoglobin is polymerized with glutaraldehyde.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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