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・ Procedural sedation and analgesia
・ Procedural surface
・ Procedural texture
・ Procedure
・ Procedure (term)
・ Procedure 769, witness to an execution
・ Procedure code
・ Proca action
・ Procabacteriaceae
・ Procaccini
・ Procacitas
・ Procaer Cobra
・ Procaer Picchio
・ Procaimanoidea
・ Procainamide
Procaine
・ Procaine benzylpenicillin
・ Procaine blockade
・ Procalcitonin
・ Procalpurnus
・ Procalpurnus lacteus
・ Procalpurnus semistriatus
・ Procalypta
・ Procalyptis
・ Procalyptis albanyensis
・ Procalyptis oncota
・ Procalyptis parooptera
・ Procambarus
・ Procambarus acherontis
・ Procambarus angustatus


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Procaine : ウィキペディア英語版
:''"Allocaine" redirects here. It should not be confused with Allococaine.''Procaine''' is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name '''Novocain''', in some regions procaine is referred to generically as '''novocaine'''. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023

:''"Allocaine" redirects here. It should not be confused with Allococaine.''
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.〔(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23〕 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.〔J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)〕
Procaine was first synthesized in 1905, shortly after amylocaine.〔
R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06〕 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it.〔 The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.〕
==Pharmacology==

The primary use for procaine is as a topical anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.〔Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93.〕 Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.〔http://www.ecstasydata.org/search.php?substance1=2023〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「:''"Allocaine" redirects here. It should not be confused with Allococaine.'''''Procaine''' is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name '''Novocain''', in some regions procaine is referred to generically as '''novocaine'''. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023」の詳細全文を読む
'Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023


:''"Allocaine" redirects here. It should not be confused with Allococaine.''
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.〔(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23〕 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.〔J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)〕
Procaine was first synthesized in 1905, shortly after amylocaine.〔
R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06〕 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it.〔 The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.〕
==Pharmacology==

The primary use for procaine is as a topical anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.〔Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93.〕 Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.〔http://www.ecstasydata.org/search.php?substance1=2023〕

抄文引用元・出典: フリー百科事典『 ''Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023">ウィキペディア(Wikipedia)
''Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023">ウィキペディアで「:''"Allocaine" redirects here. It should not be confused with Allococaine.''Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine'''. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023」の詳細全文を読む

novocaine'''. It acts mainly by being a sodium channel blocker.(DrugBank - Showing drug card for Procaine (DB00721) ) Update Date 2009-06-23 Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.J.D. Hahn-Godeffroy: Procain-Reset: Ein Therapiekonzept zur Behandlung chronischer Erkrankungen, Schweiz Z Ganzheitsmed 2011;23:291–296 (DOI:10.1159/000332021)Procaine was first synthesized in 1905, shortly after amylocaine.R. Minard, ("The Preparation of the Local Anesthetic, Benzocaine, by an Esterification Reaction" ), Adapted from ''Introduction to Organic Laboratory Techniques: A Microscale Approach'', Pavia, Lampman, Kriz & Engel, 1989. Revised 10/18/06 It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin ''nov-'' (meaning ''new'') and ''-caine'', a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it. The article was later reprinted in an August 2002 "best of Harvard Business Review" issue, and is viewable (online ) at no cost.==Pharmacology==The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog. 1992;39:187–93. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.http://www.ecstasydata.org/search.php?substance1=2023」
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