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Promescent Promescent is a topical medication〔US National Library of Medicine/National Institute of Health/DailyMed http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5b508238-3be7-4b0d-bf35-51de79f58f55〕 for the treatment of premature ejaculation. It is made by Absorption Pharmaceuticals and is available over-the-counter in the U.S. by way of FDA Monograph 21CFR 348.10.〔U.S. Food and Drug Administration (FDA) External Analgesic Drug Products for Over-The-Counter Human Use http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=348&showFR=1〕 == History ==
Promescent was invented in 2009 by doctor Ronald F. Gilbert, former chief of the Department of Urology at Hoag Hospital and assistant clinical professor of urology at UCI Medical School. Urologists had been encouraged by the success of two topical anesthetics with fast absorption lidocaine/prilocaine eutectic formulations: EMLA〔Atan, A. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation, Urology, 2006 Feb; 67(2):388-91〕 and PSD502.〔Carson, C. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study; J Sex Med 2010 Sep 7(9):3179-89. doi: 10.1111/j.1743-6109.2010.01913.x〕 However, neither of the products are approved by the FDA〔Urology Care Foundation - Urology A-Z - 〕 specifically for the treatment of PE due to prilocaine's unusual side effect of methemoglobinemia.
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