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Proser2
PROSER2, also known as proline and serine rich 2, is a protein that in humans is encoded by the ''PROSER2'' gene. ''PROSER2,'' or c10orf47'' ''(Chromosome 10 open reading frame 47), is found in band 14 of the short arm of chromosome 10 (10p14) and contains a highly conserved SARG domain.〔(NCBI (National Center for Biotechnology Information) Protein )〕〔 It is a fast evolving gene with two paralogs, c1orf116 and specifically androgen-regulated gene protein isoform 1.〔〔NCBI BLAST (National Center for Biotechnology Information ''Basic Local Alignment Search Tool'' ) ()〕〔Time Tree ()〕 The PROSER2 protein has a currently uncharacterized function however, in humans, it may play a role in cell cycle regulation, reproductive functioning, and is a potential biomarker of cancer.〔Pawlowski,T.,Yeatts, K., and Akhavan, R. (2012). Circulating biomarkers for cancer.〕〔Birrer, M.J., Bonome, T.A., Sood, A., and LU, C. (2013). Pro-angiogenic genes in ovarian tumor endothelial cell isolates.〕〔Nguyen,L.S., Kim, H.-G., Rosenfeld, J.A., Shen, Y., Gusella, J.F., Lacassie, Y., Layman, L.C., Shaffer, L.G., and Gécz, J. (2013). Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. Hum. Mol. Genet. ''22'', 1816–1825.〕〔Schettini, J., Hornung, T., Holterman, D., and Spetzler, D. (2014). Biomarker compositions
and methods.〕〔Seto, M., Tagawa, H., Yoshida, Y., and Kira, S. (2008). Methods for Diagnosis and
Prognosis of Malignant Lymphoma.〕〔Zarbl, H., and Graham, J. (2014). Novel Method of Cancer Diagnosis and Prognosis and Prediction of Response to Therapy.〕
== Gene ==
This gene is 48,880 bases in length and is 3,360 base pairs in length after transcription to mRNA.〔(NCBI (National Center for Biotechnology Information) Nucleotide )〕〔(NCBI (National Center for Biotechnology Information) Gene )〕 ''PROSER2'' has 5 splice variants, 3 of which are alternatively spliced and 2 of which are unspliced forms.〔NCBI (NationalCenter for Biotechnology Information) AceView ()〕 It contains an upstream in-frame stop codon and a 2,000 bp promoter.〔〔(Ensembl )〕
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