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Proteogenomics is an emerging field of biological research at the intersection of proteomics and genomics. While this intersection is large and can be defined in multiple ways, the term proteogenomics commonly refers to studies that use proteomic information, often derived from mass spectrometry, to improve gene annotations.〔〔. Ansong C., Purvine S. O., Adkins J. N., Lipton M. S., Smith R. D. ( 2008) Proteogenomics: needs and roles to be filled by proteomics in genome annotation. Brief. Funct. Genomics Proteomics 7, 50– 62.〕 ==Practical applications== Proteogenomics has been applied to improve the gene annotations of various organisms. The term proteogenomics was first used in this context by a Harvard team in 2004,〔Jaffe J.D., Berg H.C., Church G.M. Proteogenomic mapping as a complementary method to perform genome annotation. Proteomics. 2004a;4:59–77.〕 although the research in this field had been building up in the previous decade.〔Shevchenko A., Jensen O. N., Podtelejnikov A. V., Sagliocco F., Wilm M., Vorm O., Mortensen P., Shevchenko A., Boucherie H., Mann M. ( 1996) Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc. Natl. Acad. Sci. U.S.A 93, 14440– 14445.〕 Since then, the approach has been extended to other species including ''Arabidopsis thaliana'',〔Castellana N. E., Payne S. H., Shen Z., Stanke M., Bafna V., Briggs S. P. ( 2008) Discovery and revision of Arabidopsis genes by proteogenomics. Proc. Natl. Acad. Sci. U.S.A 105, 21034– 21038.〕 humans,〔Tanner S., Shen Z., Ng J., Florea L., Guigo R., Briggs S.P., Bafna V. Improving gene annotation using peptide mass spectrometry. Genome Res. 2007;17:231–239.〕 multiple species of ''Shewanella'' bacteria, 〔Gupta N., Tanner S., Jaitly N., Adkins J.N., Lipton M., Edwards R., Romine M., Osterman A., Bafna V., Smith R.D., et al. Whole proteome analysis of post-translational modifications: Applications of mass-spectrometry for proteogenomic annotation. Genome Res. 2007;17:1362–1377.〕〔Gupta N., Benhamida J., Bhargava V., Goodman D., Kain E., Kerman I., Nguyen N., Ollikainen N., Rodriguez J., Wang J., et al. Comparative proteogenomics: Combining mass spectrometry and comparative genomics to analyze multiple genomes. Genome Res. 2008;18:1133–1142.〕 chicken,〔McCarthy FM, Cooksey AM, Wang N, Bridges SM, Pharr GT, Burgess SC. (2006) Modeling a whole organ using proteomics: the avian bursa of Fabricius. Proteomics 6(9):2759-71.〕 among many others. Besides improving gene annotations, proteogenomic studies can also provide valuable information about the presence of programmed frameshifts, N-terminal methionine excision, signal peptides, proteolysis and other posttranslational modifications.〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Proteogenomics」の詳細全文を読む スポンサード リンク
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