翻訳と辞書 Words near each other ・ Pyriatyn Airport ・ Pyriatyn Raion ・ Pyricularia ・ Pyridazine ・ Pyridine ・ Pyridine (data page) ・ Pyridine N-methyltransferase ・ Pyridine nucleotide transferase ・ Pyridine nucleotide transhydrogenase ・ Pyridine-N-oxide ・ Pyridinium ・ Pyridinium chlorochromate ・ Pyridinium p-toluenesulfonate ・ Pyridinoline ・ Pyridinylpiperazine ・ Pyridostigmine ・ Pyridoxal ・ Pyridoxal 4-dehydrogenase ・ Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) ・ Pyridoxal kinase ・ Pyridoxal oxidase ・ Pyridoxal phosphatase ・ Pyridoxal phosphate ・ Pyridoxamine ・ Pyridoxamine-phosphate transaminase ・ Pyridoxamine—oxaloacetate transaminase ・ Pyridoxamine—pyruvate transaminase ・ Pyridoxine ・ Pyridoxine 4-dehydrogenase ・ Pyridoxine 4-oxidase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Pyridostigmine ： ウィキペディア英語版 Pyridostigmine Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and cannot penetrate across the blood–brain barrier. ==Mode of action== In a synapse, action potentials are conducted along motor nerves to their terminals where they initiate a Ca2+ influx and the release of acetylcholine (ACh). The ACh diffuses across the synaptic cleft and binds to receptors on the post synaptic membrane, causing an influx of Na+, resulting in depolarization. If large enough, this depolarization results in an action potential. To prevent constant stimulation once the ACh is released, an enzyme called acetylcholinesterase is present in the endplate membrane close to the receptors on the post synaptic membrane, and quickly hydrolyses ACh. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pyridostigmine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.