翻訳と辞書 Words near each other ・ R. Arunachalam ・ R. Ashok ・ R. Athiswami ・ R. aureum ・ R. Austin Freeman ・ R. australis ・ R-36 (missile) ・ R-360 ・ R-37 (missile) ・ R-39 Rif ・ R-390A ・ R-39M ・ R-4 (missile) ・ R-4 motorway (Spain) ・ R-40 (missile) ・ R-4066 ・ R-406A ・ R-407A ・ R-407c ・ R-410A ・ R-46 (missile) ・ R-4D ・ R-60 (missile) ・ R-7 (rocket family) ・ R-7 expressway ・ R-7 Expressway (Philippines) ・ R-7 Semyorka ・ R-73 (missile) ・ R-77 ・ R-7A Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク R-4066 ： ウィキペディア英語版 R-4066 R-4066 (Spirodone) is a drug which is an analogue of the opioid analgesic methadone, or more accurately Norpipanone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceutica, it is around 212x more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07 mg/kg, but is slightly shorter acting, with a duration of action of around 3 hours. If the ketone function is reduced and acetylated, the (R) isomer of the resultant compound is equipotent and has an analgesic duration of 20.5 hours compared to 8 hours for methadone. R-4066 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal. ==References== category:Belgian inventions 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「R-4066」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.