翻訳と辞書 Words near each other ・ Rab Noakes ・ RAB Racing ・ Rab Scott ・ Rab Se Sohna Isshq ・ Rab Shannon ・ Rab Smith ・ Rab Stewart ・ Rab Ton Sohna Ishq ・ Rab Wilson ・ Rab'-e Rashidi ・ Rab'ah ibn Umayah ・ Rab-do and Muki-do Islands Important Bird Area ・ RAB1 ・ RAB10 ・ RAB11A ・ RAB11B ・ RAB11FIP1 ・ RAB11FIP2 ・ RAB11FIP3 ・ RAB11FIP4 ・ RAB11FIP5 ・ RAB13 ・ RAB14 ・ RAB15 ・ RAB17 ・ RAB18 ・ RAB1A ・ RAB1B ・ RAB21 ・ RAB22A Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク RAB11B ： ウィキペディア英語版 RAB11B Ras-related protein Rab-11B is a protein that in humans is encoded by the ''RAB11B'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9230 )〕 Rab11b is reported as most abundantly expressed in brain, heart and testes. Rab (Ras-related in brain) proteins form the largest section of the Ras superfamily of small GTPases. The Rab family proteins regulate intracellular membrane trafficking processes including vesicle budding, tethering, and fusion. The isoforms Rab11a, Rab11b, and Rab11c/Rab25 constitute the Rab11 subfamily based on specific sequence motifs. While RAB11A is located on chromosome 15 and RAB11C on chromosome 1, RAB11B is placed on chromosome 19. Rab11 proteins are implicated in endocytosis and exocytosis. Rab11b is reported as most abundantly expressed in brain, heart and testes. Early studies with deletions of RAB11 homologs in Saccharomyces cerevisiae proved their importance in cell survival. Despite sharing high sequence homology, Rab11a and Rab11b appear to reside within distinct vesicle compartments. Majority of Rab11b neither colocalize with transferrin receptor nor with the polymeric IgA receptor. This protein also exhibits a dependence on the microtubule cytoskeleton that is different from Rab11a.〔 High sequence diversity in the C-terminal hypervariable region is responsible for variable membrane targeting between these proteins. == Function == Members of the Rab11 subfamily act in recycling of proteins from the endosomes to the plasma membrane, in transport of molecules from the trans-Golgi network to the plasma membrane and in phagocytosis. This subfamily also acts in polarized transport in epithelial cells. Whereas most studies refer to the Rab11a isoform, little is known about Rab11b so far. Rab11b localizes predominantly in the pericentriolar recycling compartment and serves as an important component of the vesicular machinery. It is required for the transfer of internalized transferrin from the recycling compartment to the plasma membrane for which active Rab11b as well as GTP hydrolysis is necessary.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RAB11B」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.