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E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the ''RAD18'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56852 )〕 ==Animal models== Model organisms have been used in the study of ''RAD18'' function. A conditional knockout mouse line, called ''Rad18tm1a(EUCOMM)Wtsi'', was generated as part of the EUCOMM program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. Mice lacking ''Rad18'' had no significant defects in viability or fertility, therefore male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.〔〔 Twenty five tests were carried out and four significant phenotypes were reported:〔 * Mutant male mice had a decreased body weight compared to wildtype control mice. * Mutant male mice showed increased activity, VO2 and energy expenditure, determined by indirect calorimetry. * Dual-energy X-ray absorptiometry (DEXA) showed mutant male mice had a decrease in fat mass. * A micronucleus test found a potential increase in DNA damage in mutant mice. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RAD18」の詳細全文を読む スポンサード リンク
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