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・ Rag Mama Rag
・ Rag Mop
・ Rag painting
・ Rag pudding
・ Rag Shankara, Rag Mala in Jogia
・ Rag Tag (film)
・ Rag, Bush and All
・ Rag, Tag and Bobtail
・ RAG-30
・ Rag-and-bone man
・ Rag-e Halil
・ Rag-i-Bibi
・ Rag-stone
・ Rag. Arturo De Fanti, bancario precario
・ RAG1
RAG2
・ Raga
・ Raga (Buddhism)
・ Raga (disambiguation)
・ Raga (film)
・ Raga Airport
・ Raga Darbari
・ Raga language
・ Raga Mala (book)
・ Raga Music
・ Raga rock
・ Raga Rockers
・ Raga, Bhutan
・ Raga, South Sudan
・ Ragab Abdelhay


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RAG2 : ウィキペディア英語版
RAG2

Recombination activating gene 2 also known as RAG-2 is a protein that in humans is encoded by the RAG2 gene.〔 〕
== Function ==

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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