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ROCK1
ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effecter of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.〔
== Gene and expression ==
ROCK1 is also the name of the gene that encodes the protein ROCK1, a serine/thronine kinase. ROCK1 is activated when bound to the GTP-bound form of RhoA. The human ROCK1 gene is located on human chromosome 18 with specific location of 18q11.1.〔(【引用サイトリンク】Homo sapiens (human) )"> url = http://www.ncbi.nlm.nih.gov/gene/6093 )〕 The location of the base pair starts at 18529703 and ends at 18691812 bp and translates into 1354 amino acids.〔(【引用サイトリンク】 url = http://www.genecards.org/cgi-bin/carddisp.pl?gene=ROCK1 )〕
ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization.〔 In rats, ROCK1 is expressed in the lung, liver, spleen, kidney, and testis.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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