翻訳と辞書 Words near each other ・ Roddy Llewellyn ・ Roddy Lorimer ・ Roddy Lumsden ・ Roddy MacLennan ・ Roddy MacLeod ・ Roddy Manley ・ Roddy Maude-Roxby ・ Rod Woodward ・ Rod Wright ・ Rod Young ・ Rod Zaine ・ Rod Zimmer ・ Rod Zullo ・ Rod's Pot ・ Rod, Jane and Freddy ・ ROD-188 ・ Rod-and-ring symbol ・ RodA ・ Roda ・ Roda (formation) ・ Roda (megamarkets) ・ Roda (river) ・ Roda Ali Wais ・ Roda Antar ・ Roda Codex ・ Roda de Berà ・ Roda de Eresma ・ Roda de Isábena ・ Roda de Mundo ・ Roda de Ter Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク ROD-188 ： ウィキペディア英語版 ROD-188 ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche.〔US Patent 6649626 N-substituted 1-(lactone) isoquinolones for treating nervous disorders〕 Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor.〔Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E. A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. ''British Journal of Pharmacology''. 2000 Oct;131(4):843-50. PMID 11030736〕 ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors.〔Sigel E, Baur R, Furtmueller R, Razet R, Dodd RH, Sieghart W. Differential cross talk of ROD compounds with the benzodiazepine binding site. ''Molecular Pharmacology''. 2001 Jun;59(6):1470-7. PMID 11353808〕 == See also == * Bicuculline 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ROD-188」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.