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RTI-112 (2β-carbomethoxy-3β-(3-methyl-4-chlorophenyl)tropane) is a synthetic stimulant drug from the phenyltropane family. In contrast to RTI-113, which is DAT selective, RTI-112 is a nonselective triple reuptake inhibitor.〔() Ginsburg, B.C., Kimmel, H.L., Carroll, F.I., Goodman, M.M., Howell, L.L. Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys. Pharmacology Biochemistry and Behavior, 80: 481-491, 2005.〕 ''In vitro'' tests show a very similar serotonin transporter (SERT)/dopamine transporter (DAT)/norepinephrine transporter (NET) selectivity to cocaine,〔 although in vivo behaviour is different: "The nonselective monoamine transporter inhibitor RTI-126 and the DAT-selective inhibitors RTI-150 and RTI-336 both had a faster rate of onset (30 min) and a short duration of action (4h). In contrast, the nonselective monoamine transporter inhibitor RTI-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). The DAT-selective inhibitors RTI-171 and RTI-177 also had slower rates of onset (30–120 min), but RTI-171 had a short duration of action (2.5 h) while RTI-177 had a very long duration of action (20 h)."〔 The efficacy of cocaine analogs to elicit self-administration is related to the rate at which they are administered. Slower onset analogs are less likely to function as behavioral stimulants than analogs eliciting a faster rate of onset. Nonselective analogs are less likely to function as "reinforcers" than reuptake inhibitors that have DAT specificity. In order for a dopamine reuptake inhibitor (DRI) such as cocaine to induce euphoria, PET scans on primates reveal that the DAT occupancy needs to be >60%.〔() Howell, L.L. and Wilcox, K.M. "The dopamine transporter and cocaine medication development: Drug self-administration in nonhuman primates." ''Journal of Pharmacology and Experimental Therapeutics'', 298: 1-6, 2001.〕 RTI-112 has equipotent in vitro affinity at the SERT, NET and DAT, respectively.〔 RTI-112 was not reliably self-administered, in contrast to the DAT selective reuptake inhibitors that were used in this study.〔() Lindsey, K.P., Wilcox, K.M., Votaw, J.R., Goodman, M.M., Plisson, C., Carroll, F.I., Rice, K.C., Howell, L.L. (2004) "Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging." ''Journal of Pharmacology and Experimental Therapeutics'', 309: 959-969〕 In vivo at the ED50, RTI-112 had no DAT occupancy at all.〔 At the ED50, almost all of the RTI-112 occupied the SERT at this dose.〔 A significantly higher dose was required to get >70% DAT occupancy in the case of RTI-112;〔 however, RTI-112 was still able to suppress cocaine administration at the ED50, suggesting a serotonergic mechanism was responsible for this.〔 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RTI-112」の詳細全文を読む スポンサード リンク
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