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RTI-274, or 2β-((3,4-Methylenedioxyphenoxy)methyl)-3α-(4-fluorophenyl)nortropane is a phenyltropane homologue of paroxetine developed by the group led by F Ivy Carroll in the 1990s. ==Introduction== Very few ethers of phenyltropanes are actually known to have been reported. NS2330 and NS2359 both have α,β stereochemistry. NS2214 appears to have been abandoned now, RTI-336 was their latest compound. RTI decided that they wanted to make all 8 stereoisomers of the phenyltropane paroxetine homolog.〔 *''N''-demethylating the S-α,β (1S,2S,3R) isomer resulted in a 54-fold increase in DAT IC50. In the case of nocaine it is understood that the SR enantiomer is the one that should be demethylated if it is wanted to improve DAT affinity. Interestingly, that is actually the same enantiomer that is used in the production of paroxetine. 400px 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RTI-274」の詳細全文を読む スポンサード リンク
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