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RegulonDB
RegulonDB is a database of the regulatory network of Escherichia coli K-12. RegulonDB defines a schema to model the complex regulation of transcription initiation or regulatory network of the ''E. coli'' K-12 cell. On the other hand, it is also a model of the organization of the genes in transcription units, operons and simple and complex regulons. In this regard, RegulonDB is a computational model of mechanisms of transcriptional regulation.
== Introduction ==
Most of the times, regulatory elements occur upstream of operons. However, there is a good number of regulatory elements (promoter and binding sites) located inside a promoter, defining a different transcription unit.
An important aspect to keep in mind in order to avoid misunderstandings in the content of a database, is the fact that our current understanding and characterization of different genes, operons and regulatory mechanisms, is quite variable. For some genes, their mechanisms are very well described, whereas in other cases there is no regulation defined for a given promoter, or a promoter has been characterized upstream of a poorly characterized operon or transcription unit. Our definitions and conventions affect not only the way well-characterized systems are described, but also the way the lack of information is taken into consideration.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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