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Remimazolam
Remimazolam〔EP Patent 1183243〕 (CNS-7056) is a benzodiazepine derivative drug, developed by PAION, in collaboration with Japanese licensee Ono Pharmaceutical as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. Remimazolam was found to be both faster acting and shorter lasting than midazolam, and human clinical trials showed a faster recovery time and predictable, consistent pharmacokinetics, suggesting some advantages over existing drugs for these applications.
== Trials ==
Phase I and Ib dose-finding studies for procedural sedation with patients recovering faster from Remimazolam than midazolam. Phase II trials comparing Remimazolam to the standard anaesthesia protocols for cardiac surgery and colonoscopy were presented at major conferences in October 2014.
A phase 2a trial comparing remimazolam to midazolam for upper endoscopy was published in December 2014, finding a similar safety profile.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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