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Repression of heat shock gene expression (ROSE) element : ウィキペディア英語版 | Repression of heat shock gene expression (ROSE) element
__NOTOC__ The repression of heat shock gene expression (ROSE) element is an RNA element found in the 5' UTR of some heat shock protein's mRNAs. The ROSE element is an RNA thermometer that negatively regulates heat shock gene expression. The secondary structure is thought to be altered by temperature, thus it is an RNA thermometer. This structure blocks access to the ribosome binding site at normal temperatures. During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur. A partial structure of this RNA element has been determined using NMR.〔 ==ROSE1 and ROSEAT2== ROSE1 and ROSEAT2 are specific examples of ROSE elements. ROSE1 is found in ''Bradyrhizobium japonicum'' whereas ROSEAT2 is a closely related element from ''Agrobacterium tumefaciens''. The two RNA elements have similar secondary structures with ROSE1 having an extra hairpin.〔 All ROSE elements contain a characteristic 'bulged G' opposite the Shine-Dalgarno sequence binding site, without this nucleotide the RNA thermometer loses its temperature-sensitivity.
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