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The gene ''reprimo'' has been found to be downregulated in several cancers but rarely in healthy cells. Its role appears to be related to its interaction with p53 (tumor protein 53). The gene is methylated, sometimes in pre-cancerous growths and may be an early cancer indicator. Reprimo has also been found to be associated with the development of esophageal adenocarcinaoma (see Esophageal cancer), and could be a potential biomarker for early detection.. Recent work suggest that Reprimo might be a potential non-invasive biomarker for early detection in gastric cancer since it has been found in plasma samples of gastric cancer patients (>90%) but rarely (10%) in plasma of healthy donors . == References == * * * Bernal C, Aguayo F, Villarroel C, Vargas M, Díaz I, Ossandon FJ, Santibáñez E, Palma M, Aravena E, Barrientos C, Corvalan AH. Reprimo as a potential biomarker for early detection in gastric cancer. Clin Cancer Res. 2008;14:6264-9. PMID 18829507 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Reprimo」の詳細全文を読む スポンサード リンク
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