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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Resminostat ： ウィキペディア英語版 Resminostat |Section2= |Section3= }} Resminostat (RAS2410) is an orally bioavailable inhibitor of histone deacetylases (HDACs), of which inhibitors are antineoplastic agents.〔(【引用サイトリンク】title=Biological activity of resminostat in selleck chemicals research )〕 In 2011, the German drug maker 4SC was granted orphan drug designation for resminostat by the Food and Drug Administration for the treatment of hepatocellular cancer/HCC.〔(【引用サイトリンク】title=4SC's Anti-Cancer Drug Resminostat achieves Median Overall Survival of 8.0 Months in Second-Line Advanced Liver Cancer (HCC) Patients )〕 == Mechanism == Resminostat restrains the phosphorylation of 4E-BP1 and p70S6k, indicating an disturbance with Akt signalling pathway.The treatment of resminostat leads to a drop of Bim and Bax protein level and Bcl-xL level. As with other inhibitors such as pracinostat, the inhibition of HDACs by resminostat results in an accumulation of highly acetylated histones, followed by an abduction of chromatin remodeling, inhibition of tumor suppressor genes transcription and cell division, and finally tumor cell apoptosis. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Resminostat」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.