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Modern biological research has revealed strong evidence that the enzymes of the mitochondrial respiratory chain assemble into larger, supramolecular structures called respirasomes or supercomplexes, instead of the traditional fluid model of discrete enzymes dispersed in the inner mitochondrial membrane. These supercomplexes are functionally active and necessary for forming stable respiratory complexes. Respirasomes have been found in a variety of species and tissues, including rat brain,〔 〕 liver,〔 kidney,〔 skeletal muscle,〔 heart,〔 bovine heart,〔 〕 human skin fibroblasts,〔 〕 fungi,〔 〕 plants, and C. elegans. ==History== In 1955, biologists Britton Chance and G. R. Williams were the first to propose the idea that respiratory enzymes assemble into larger complexes, although the fluid state model remained the standard. However, as early as 1985, researchers had begun isolating Complex III/Complex IV supercomplexes from bacteria and yeast. Finally, in 2000 Hermann Schägger and Kathy Pfeiffer used Blue Native PAGE to isolate bovine mitochondrial membrane proteins, showing Complex I, III, and IV arranged in supercomplexes. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Respirasome」の詳細全文を読む スポンサード リンク
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