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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Rex1 ： ウィキペディア英語版 Rex1 Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state. As the cells begin to differentiate, Rex1 is severely and abruptly downregulated. ==Discovery== Rex1 was discovered by Hosler, BA et al. in 1989 when studying F9 murine teratocarcinoma stem cells. They found that these teratocarcinoma stem cells expressed high levels of Rex1, and that they resembled pluripotent stem cells of the inner cell mass (ICM).〔http://www.sigmaaldrich.com/life-science/your-favorite-gene-search/gene-detail-pages/rex1.html〕 Hosler, BA et al. found that these teratocarcinoma stem cells, when in the presence of retinoic acid (RA), differentiated into nontumorigenic cells resembling extraembryonic endoderm of early mouse embryos. They were able to isolate the nucleotide sequence for Rex1 using differential hybridization of an F9 cell. They named it Rex1 for reduced expression 1 because there was a steady decline of its mRNA levels within 12 hours of the addition of RA.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Rex1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.