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・ Rs1800532
・ Rs1800955
・ Rs1801133
・ Rs1805054
・ Rs1954787
・ RS2
・ RS200
・ RS200 (dinghy)
・ RS280
・ Rs28363170
・ RS3
・ RS300
・ RS3m
・ RS4 Codici
・ RS400
Rs4680
・ RS500
・ Rs5569
・ RS600
・ RS600FF
・ Rs6265
・ Rs6294
・ Rs6295
・ Rs6311
・ Rs6313
・ Rs6314
・ RS700
・ Rs7341475
・ Rs7997012
・ RS800


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Rs4680 : ウィキペディア英語版
Rs4680

In genetics, rs4680 (Val158Met) is a genetic variant.
It is a single nucleotide polymorphism (SNP) in the ''COMT'' gene that codes catechol-''O''-Methyltransferase.
The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158.
The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.
The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the ''SzGene'' database shows no or very little effect.〔http://www.szgene.org/meta.asp?geneID=420&polyID=2954〕
Several personality genetics studies have examined the association of the polymorphism with personality traits.
== References ==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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