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A rubefacient is a substance for topical application that produces redness of the skin e.g. by causing dilation of the capillaries and an increase in blood circulation. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy;〔Matthews et al. 2009 (''Topical rubefacients for acute and chronic pain in adults'' ) Cochrane Database Syst Rev. 2009 (3):CD007403〕〔Mason et al. 2004 (''Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain'' ) BMJ 328:995〕 and as of 2010 the best evidence does not support using gels and creams containing rubefacients for this purpose. ==Examples== Common medicinal rubefacients include:〔 *Salicylates (such as Oil of Wintergreen, ''Methyl Salicylate'') *Nicotinate esters *Capsaicin (derived from Cayenne, ''Capsicum minimum'') "incites irritation without rubefaction" *Isopropanol (rubbing alcohol) *Menthol *Minoxidil Common herbal rubefacients include: *Cloves (''Syzygium aromaticum'') *Garlic (''Allium sativum'') *Ginger (''Zingiber officinale'') *Horseradish ''(Cochlearia armoracia'') *Mustard (''Brassica alba'' or ''Brassica nigra'') *Nettle (''Urtica dioica'') *Rosemary Oil (''Rosmarinus officinalis'') *Rue (''Ruta graveolens'') *Peppermint (''MENTHA PIPERITA'') 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Rubefacient」の詳細全文を読む スポンサード リンク
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