翻訳と辞書 Words near each other ・ S-(hydroxymethyl)glutathione dehydrogenase ・ S-(hydroxymethyl)glutathione synthase ・ S-(hydroxymethyl)mycothiol dehydrogenase ・ S-1 block cipher ・ S-1 Gard ・ S-1 Lisp ・ S-1 Uranium Committee ・ S-100 bus ・ S-125 Neva/Pechora ・ S-13 rocket ・ S-130/S-190 training courses ・ S-14,506 ・ S-14671 ・ S-15535 ・ S-160 ・ S-17092 ・ S-18986 ・ S-1990 ・ S-200 (bioremediation) ・ S-200 (missile) ・ S-210 ・ S-23 (drug) ・ S-24 rocket ・ S-25 (rocket) ・ S-25 Berkut ・ S-300 (missile) ・ S-300VM ・ S-310 ・ S-350 ・ S-400 (missile) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク S-17092 ： ウィキペディア英語版 S-17092 S-17092 is a drug which acts as a selective inhibitor of the enzyme prolyl endopeptidase.〔Barelli H, Petit A, Hirsch E, Wilk S, De Nanteuil G, Morain P, Checler F. S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase. ''Biochemical and Biophysical Research and Communications''. 1999 Apr 21;257(3):657-61. PMID 10208839〕 This enzyme is involved in the metabolic breakdown of a number of neuropeptide neurotransmitters in the brain,〔Bellemère G, Morain P, Vaudry H, Jégou S. Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. ''Journal of Neurochemistry''. 2003 Mar;84(5):919-29. PMID 12603817〕〔Bellemère G, Vaudry H, Morain P, Jégou S. Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain. ''Journal of Neuroendocrinology''. 2005 May;17(5):306-13. PMID 15869566〕 and so inhibiting the action of the enzyme increases the activity of these neuropeptides. This produces nootropic effects which make S-17092 a promising and novel treatment for neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease.〔Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, Boyer PA. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. ''CNS Drug Reviews''. 2002 Spring;8(1):31-52. PMID 12070525〕〔Morain P, Boeijinga PH, Demazières A, De Nanteuil G, Luthringer R. Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers. ''Neuropsychobiology''. 2007;55(3-4):176-83. PMID 17700042〕 ==See also== * C16 (PKR inhibitor) * UK-414,495 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「S-17092」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.