翻訳と辞書 Words near each other ・ S-Type ・ S-Type (Music) ・ S-type asteroid ・ S-type star ・ S-unit ・ S-VHS ・ S-24 rocket ・ S-25 (rocket) ・ S-25 Berkut ・ S-300 (missile) ・ S-300VM ・ S-310 ・ S-350 ・ S-400 (missile) ・ S-40503 ・ S-444,823 ・ S-45 (satellite) ・ S-45A ・ S-5 rocket ・ S-50 (Manhattan Project) ・ S-500 (missile) ・ S-520 ・ S-550 (spacecraft) ・ S-63 (encryption standard) ・ S-75 Dvina ・ S-8 rocket ・ S-80-class submarine ・ S-94 (film) ・ S-acylation ・ S-Adenosyl methionine Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク S-444,823 ： ウィキペディア英語版 S-444,823 S-444,823 is a drug developed by Shionogi which is a cannabinoid agonist.〔(Arimura A. Novel Use of Cannabinoid Receptor Agonist. Patent WO 2005/016351 )〕 It was developed as an antipruritic, and has moderate selectivity for the CB2 subtype, having a CB2 affinity of 18nM, and 32x selectivity over the CB1 receptor. In animal studies it showed analgesic effects and strongly reduced itching responses, but without producing side effects such as sedation and catalepsy that are seen with centrally acting CB1 agonists.〔Odan M, ''et al.'' Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent. ''Bioorganic and Medicinal Chemistry Letters''. 2012 Apr 15;22(8):2898-901. PMID 22421019〕 ==See also== * JTE 7-31 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「S-444,823」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.