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Levamlodipine (INN), also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. Levamlodipine is currently marketed in Russia under the brand name EsCordi Cor (Actavis Pharma) and in India under the trade names Eslo (Zuventus Healthcare Ltd.), Asomex (Emcure Pharmaceutical Ltd), and Espin (Intas Pharmaceuticals Ltd). == Mechanism of action == Amlodipine blocks the transmembrane influx of calcium into the vascular and cardiac smooth muscles resulting in vasodilation and hence a fall in blood pressure. Levamlodipine is an allosteric modulator and acts on the L-type of calcium channels. Receptor binding studies have shown that out of the two forms only the (''S'')-enantiomer of amlodipine binds to and blocks L-type calcium channels whereas the (''R'')-enantiomer has no activity on these channels. The precise mechanisms by which levamlodipine relieves angina have not been fully explored, but are thought to include the following: * Decreases peripheral resistance by arteriolar vasodilatation leading to the reduction in oxygen requirement and energy consumption of cardiac smooth muscles. * Decreases coronary vascular resistance and can lead to an increase in coronary blood flow.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Levamlodipine」の詳細全文を読む スポンサード リンク
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