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S-equol
''S'' -Equol () is a metabolite of the soy isoflavone daidzein. ''S''-equol thus is characterized as an isoflavan. It is not of plant origin. Rather, ''S''-equol is produced by intestinal bacteria in some, but not in all, humans after soy consumption. The ability of ''S''-equol to play a role in the treatment of estrogen or androgen-mediated diseases or disorders was first proposed in 1984. Although still under investigation, the ability to produce ''S''-equol may be associated with other health benefits, according to data from epidemiological and intervention studies. Studies in both animal models and humans have yielded data about the potential of ''S''-equol use in menopause, breast, bone and prostate health. Supplements containing ''S''-equol are under development, and testing in humans is ongoing for the management of menopausal symptoms, including the reduction in the frequency and severity of hot flashes as well as neck and shoulder stiffness.
== History ==
Equol was first isolated from horse urine in 1932, and the name was suggested by this equine connection. Since then, equol has been found in the urine or plasma of many other animal species, although these animals have significant differences in their effectiveness in metabolizing the soy isoflavone daidzein into equol. In 1980, scientists reporting the discovery of equol in humans. The ability of ''S''-equol to play a role in the treatment of estrogen- or androgen-mediated diseases or disorders was first proposed in 1984.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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