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SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the ''SAMHD1'' gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. It is an enzyme that exhibits phosphohydrolase activity, converting nucleotide triphosphates (NTPs) to triphosphate and a nucleoside (i.e. nucleotides without a phosphate group). In doing so, SAMHD1 depletes the pool of NTPs available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication. SAMHD1 has also shown nuclease activity,〔Beloglazova N, Flick R, Tchigvintsev A, Brown G, Popovic A, Nocek B, Yakunin AF. “Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction”. 〕 and a ribonuclease activity has been recently described to be required for HIV-1 restriction. == Nomenclature == The SAMHD1 protein is also known as: * AGS5: Aicardi- Goutières syndrome type 5 * DCIP: Dendritic cell-derived IFNG-induced protein2 * Mg11: Interferon-gamma-inducible protein〔 * HDDC1: HD domain containing 1 * MOP-5: Monocyte protein 5 * SAMH1_HUMAN * SBBI88 * CHBL2 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SAMHD1」の詳細全文を読む スポンサード リンク
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