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SC-17599
SC-17599 is a steroid derivative drug discovered in 1968 which acts as a selective μ-opioid receptor agonist, with little or no affinity for the δ-opioid or κ-opioid receptors. It is an active analgesic ''in vivo'', more potent than codeine or pethidine but slightly less potent than morphine,〔Craig CR. Analgetic Activity and Other Pharmacological Properties of a Steroid; 17α-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one Hydrochloride (SC17599) ''Journal of Pharmacology And Experimental Therapeutics'' 1968; 164(2):371-379.〕 and produces similar effects to morphine in animals but with less sedation.〔McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. ''Molecular Pharmacology''. 2000 Oct;58(4):669-76. PMID 10999935〕〔Houshyar H, Mc Fadyen IJ, Woods JH, Traynor JR. Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor. ''European Journal of Pharmacology''. 2000 Apr 28;395(2):121-8. PMID 10794817〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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