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SERPINB10
Serpin peptidase inhibitor, clade B (ovalbumin), member 10 is a protein that in humans is encoded by the SERPINB10 gene.
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(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/5273 )〕
==Function==
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (2690952 )). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (9268635 )).(by OMIM, Jan 2010 ). ##Evidence-Data-START## Transcript exon combination :: BC096217.3, U35459.1 () RNAseq introns :: mixed/partial sample support ERS025084, ERS025087 () ##Evidence-Data-END##
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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