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SGN-CD33A
SGN-CD33A is an antibody-drug conjugate (ADC) directed to CD33 designed for the treatment of Acute myeloid leukemia. It consists of a humanized anti-CD33 mAb with 2 engineered cysteine residues. The drug payloads are pyrrolobenzodiazepine (PBD) dimers which are conjugated with a maleimidocaproyl valine-alanine dipeptide linker. PBD dimers exert their biological activity by covalent binding and interstrand cross-linking of DNA.〔https://ash.confex.com/ash/2012/webprogram/Paper48592.html〕 The drug is currently in phase I clinical trials for Acute myeloid leukemia 〔(Clinicaltrials.gov )〕 == References ==
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