翻訳と辞書 Words near each other ・ Sgùrr nan Clach Geala ・ Sgùrr nan Each ・ Sgùrr nan Eugallt ・ Sgùrr nan Gillean ・ Sgùrr Thuilm ・ SH ・ Sh (digraph) ・ SH 760 ・ SH Triumph ・ Sh! ・ Sh! The Octopus ・ Sh! Women's Erotic Emporium ・ Sh'Chur ・ Sh'erit ha-Pletah ・ Sh'or Yoshuv ・ SH-053-R-CH3-2′F ・ SH-760 ・ SH-AWD ・ Sh-Boom ・ Sh-K-Boom Records ・ SH-SY5Y ・ Sh-Tandem ・ SH1 ・ SH1 (classification) ・ SH101 ・ SH2 ・ SH2 (classification) ・ SH2 domain ・ Sh2-1 ・ Sh2-101 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SH-053-R-CH3-2′F ： ウィキペディア英語版 SH-053-R-CH3-2′F SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α5 subtype of the GABAA receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses.〔Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? ''Neuropsychopharmacology''. 2008 Jan;33(2):332-9. PMID 17392731〕 SH-053-R-CH3-2′F also blocks the nootropic effects of the α5-selective inverse agonist PWZ-029, so amnesia is also a likely side effect.〔Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. ''Brain Research''. 2008 May 7;1208:150-9. PMID 18394590〕 ==See also== *QH-ii-066 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SH-053-R-CH3-2′F」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.