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SH-SY5Y
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SH-SY5Y : ウィキペディア英語版
SH-SY5Y

SH-SY5Y is a human derived cell line used in scientific research. The original cell line, called SK-N-SH, from which it was subcloned was isolated from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. SH-SY5Y cells are often used as ''in vitro'' models of neuronal function and differentiation. They are adrenergic in phenotype but also express dopaminergic markers and, as such, have been used to study Parkinson's Disease.
==History==
SH-SY5Y was cloned from a bone marrow biopsy derived line called SK-N-SH and first reported in 1973. A neuroblast-like subclone of SK-N-SH, named SH-SY, was subcloned as SH-SY5, which was subcloned a third time to produce the SH-SY5Y line, first described in 1978. The cloning process is essentially artificial selection, involving expansion of individual cells or a small group of cells that express a particular phenotype of interest, in this particular case neuron-like characteristic. The SH-SY5Y line is genetically female with two X and no Y chromosome, as expected given an origin from a four-year-old female.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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