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SIM2 Single-minded homolog 2 is a protein that in humans is encoded by the ''SIM2'' gene.〔 It plays a mojor role in the development of the CNS midline as well as the construction of the face and head.〔 == Function ==
SIM1 and SIM2 genes are ''Drosophila'' single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of neurogenesis of midline cells in the central nervous system. SIM2 maps within the so-called Down syndrome chromosomal region, specifically on the q arm of chromosome 21, band 22.2.〔 Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6493 )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「SIM2」の詳細全文を読む
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