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SIR-Spheres SIR-Spheres microspheres is used to treat patients with unresectable liver cancer. These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC), or metastatic neuroendocrine tumours (mNET).〔J.I.Bilbao & M.F.Reiser: Liver Radioembolization with Yttrium-90 Microspheres, Springer 2008 ISBN 978-3-540-35421-5〕 Therapy goals are local disease control, downstaging to resection, bridging to transplantation, and extended survival.〔R.Salem et al J.Vasc Intervent Radiol 2006; 17:1251-1278〕 ==Description== SIR-Spheres microspheres contain resin based microspheres with an average diameter between 20 and 60 micrometre. The microspheres are impregnated with 90Y, a beta radiating isotope of yttrium with a half-life of 64.1 hours.〔http://www.sirtex.com/content.cfm?sec=usa&MenuID=1120〕
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