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SKAP1
Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the ''SKAP1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631 )〕
The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse.〔Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75.〕 Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.〔 *〕〔Schneider H., Wang H., Raab M., Valk E., Smith X. , Lovatt M., Wu Z., Strebhardt K, Rudd, CE. Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.〕 ==Interactions== SKAP1 has been shown to interact with FYN,〔 PTPRC and FYB.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「SKAP1」の詳細全文を読む
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