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S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the ''SKP1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6500 )〕 This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. == Interactions == SKP1A has been shown to interact with: * BTRC,〔〔〔 * CACYBP, * CDCA3, * CDK9, * CUL1,〔 * FBXL3, * FBXO4,〔 * FBXO5,〔 * FBXO7,〔 * FBXW2,〔 * FBXW7,〔 and * SKP2.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SKP1A」の詳細全文を読む スポンサード リンク
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